Symbol
Name
ID

Nos3
nitric oxide synthase 3, endothelial cell
MGI:97362

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Persistence of hemoglobin F

Increased mean corpuscular volume

Reticulocytosis

Hemolytic anemia

Chronic hemolytic anemia

Increased red cell sickling tendency

Hypochromic anemia

Iron deficiency anemia

Microcytic anemia

Target cells

Leukocytosis

Acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemias

Acute myeloid leukemia

Superficial thrombophlebitis

Thrombocytosis

Lymphoma

Abnormality of the spleen

Splenic infarction

Splenomegaly

Hepatosplenomegaly

Disease(s) Associated with NOS3

acute lymphoblastic leukemia

acute myeloid leukemia

Behcet's disease

cystic fibrosis

sickle cell anemia

Mouse Phenotypes		enhanced leukocyte tethering or rolling	abnormal leukocyte adhesion	enlarged spleen	increased basophil cell number	increased eosinophil cell number	increased neutrophil cell number	decreased lymphocyte cell number	abnormal spleen morphology	abnormal neutrophil physiology	abnormal osteoclast physiology
Availability	Mouse Genotype	enhanced leukocyte tethering or rolling	abnormal leukocyte adhesion	enlarged spleen	increased basophil cell number	increased eosinophil cell number	increased neutrophil cell number	decreased lymphocyte cell number	abnormal spleen morphology	abnormal neutrophil physiology	abnormal osteoclast physiology
	Nos3^em1(IMPC)Mbp/Nos3^em1(IMPC)Mbp
	Nos3^tm1Plh/Nos3^tm1Plh
	Nos3^tm1Unc/Nos3^tm1Unc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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